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  • 15/07/2012 at 7:46 am #10722
    drmithila
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    Registered On: 14/05/2011
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    Guwahati, June 24 (IANS) After performing corrective surgeries on over 6,000 children in the past two years, NGO Operation Smile India’s Comprehensive Cleft Care Centre here is now reaching out to those in need in other parts of the northeast and neighbouring countries like Bangladesh, Bhutan and Myanmar.
    The centre is one of the three the NGO runs in India to take care of cleft lips and other related deformities like palate deformities, as also dental and nutritional problems and speech therapy among children free of cost.
    “We are planning to reach out to the thousands of children with cleft lips and palate deformities in at least two states in the northeast region and three neighbouring countries – Bangladesh, Bhutan and Myanmar,” Centre director Mahesh Deuri told IANS.
    “While we have already contacted the Meghalaya government and received a response from them. Talks have been initiated with the neighbouring countries through the respective consulates of those countries,” Deuri added.
    Deuri plans to launch the first cleft-lip mission in Meghalaya by August.
    The Centre was established in 2010 in the campus of the Mahendra Mohan Chouhdury Hospital in Guwahati, through the efforts of Operation Smile India, the Assam government, the National Rural Health Mission and the Sir Dorabji Tata Trust and its allied trusts.
    The Assam government provides free accommodation and also bears the travel expenses of patients and their caretakers. Besides, the NRHM has also engaged Accrediated Social Health Activists (ASHAs) to identify patients. ASHAs get Rs.50 per patient to bring them to the centre.
    At Rs.40,000, the operations don’t come cheap. So, where does the money come from?
    Deuri wouldn’t disclose the annual budget as it varies from year to year, but explained: “We approach our donors every year with an estimate of surgeries. We go ahead when we get a green signal from our donors, which are mainly the Assam government and the Sir Dorabji Tata Trust and its allied trusts. For the 2012-13 financial year, our target is to conduct 3,500 surgeries,” Deuri said.
    That would entail a staggering Rs.140 million, but given the generosity of the trusts involved, raising the money shouldn’t be much of a problem.
    “Initially one surgery and comprehensive care used to cost around Rs.90,000 as we did not have the economies of scale. Now the cost of an operation has reduced by more than 50 percent as the number of patients has increased,” Deuri said.
    The Guwahati centre has eight beds, of which four to five are occupied every day. It has 11 full-time doctors – four plastic surgeons, four anesthesiologists, two pediatricians and a nutritionist. Dentists and speech therapists are also on call.
    According to the World Health Organization, cleft lips and palette deformities occur in one in every 700 live births across the globe.
    “In India, about 35,000 children are born with cleft-lip deformities. Though completely treatable, very few get the care they desperately need due to the lack of resources and awareness. Without corrective surgeries, these children are condemned to a lifetime of isolation and suffering,” said Dipul Malakar, Operation Smile India’s communication officer in Assam.
    “In Assam too, approximately 1,000 children are born with cleft-lip deformities every year,” Malakar added.
    (Anup Sharma can be contacted at anup.s@ians.in)

            

    14/09/2012 at 5:10 pm #15923
    Drsumitra
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    Registered On: 06/10/2011
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    In a study newly published in the journal Development, investigators at the USC School of Dentistry describe how to non-surgically reverse the onset of cleft palate in fetal mice — potentially one step in the journey to a better understanding of similar defects in humans
    Yang Chai, the study’s principal investigator and director of the School of Dentistry’s Center for Craniofacial Molecular Biology, said that cleft palate is one of the most common congenital birth defects in humans and that current surgical treatment for the craniofacial abnormality is often complex and invasive, sometimes stretching over a period of years before the treatment is considered complete.
    Cleft palate can cause serious complications, including difficulty eating and learning to speak. However, close regulation of important signaling molecules during palate formation may one day allow doctors to reverse a cleft palate before the baby is even born, Chai said.
    For example, the protein Shh must remain within a certain level in a developing fetus in order for a proper palate to form. If too little or too much of the protein is expressed, a cleft palate can occur.
    Two genes are responsible for the regulation of Shh levels. Signaling from the Msx1 gene encourages Shh production, while Dlx5 discourages Shh, creating a healthy balance. Both genes are critical for the healthy development of the palate, teeth and other skull and facial structures.
    The fetal mice were strategically bred to have a defect in the Msx1 gene, resulting in lack of expression of the Shh protein and the formation of cleft palates. However, when the impact of the Dlx5 gene was suppressed, more Shh was successfully expressed and the palate began to regrow.
    When the mice were born, their palates were intact. While some of the oral structures had minor differences as compared to the palates in completely healthy mice, the function of the rescued palates were healthy, allowing the newborn mice to feed normally.
    With more research into the genetic processes behind cleft palate in humans, the breakthrough could someday make a big difference in how we prevent or treat cleft palate in humans, Chai said.

     

            

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