Highly flexible fingers and toes
Loose, unstable joints that are prone to: sprain, dislocation, subluxation (partial dislocation) and hyperextension (double jointedness)
Flat feet
Joint pain without inflammation
Fatigue, which can be debilitating
High and narrow palate, resulting in dental crowding
Vulnerability to chest and sinus infections
Easy bruising
Fragile blood vessels resulting from cystic medial necrosis with tendency towards aneurysm (even abdominal aortic aneurysm)
Velvety-smooth skin which may be stretchy and is often translucent, with blue veins clearly visible on limbs and particularly in the hands
Abnormal wound healing and scar formation (scars may appear like cigarette burns)[citation needed]
Low muscle tone and muscle weakness
Early onset of osteoarthritis
Cardiac effects: Dysautonomia typically accompanied by Valvular heart disease (such as mitral valve prolapse, which creates an increased risk for infective endocarditis during surgery, as well as possibly progressing to a life-threatening degree of severity of the prognosis of mitral valve prolapse)
Unexplained “pins and needles” or numbness in extremities
Difficulty regulating own body temperature, resulting in a vulnerability to the cold and heat. Many patients suffer fatigue and dizziness when exposed to hot conditions, eg. having to sit outside on a hot day
Severe mouth ulcers. Many patients complain of having several mouth ulcers at any one time. This is believed to be due to tissue fragility and vulnerability to infection
Food allergies and intolerances are very common
Sensitivity to medications. One of the cruelest aspects of EDS is that many patients experience bad reactions to medications, such as pain killers, making it very difficult to find safe, effective pain management[citation needed]
Insensitivity to the dental anesthesia Lidocaine.
Migraines and headaches, including postural headaches from spontaneous intracranial hypontension
Fibromyalgia symptoms: Myalgia and arthralgia
Other, less common signs and complications may include:
Osteopenia (low bone density)
Talipes equinovarus (club foot), especially in the Vascular type
Deformities of the spine, such as: Scoliosis (curvature of the spine), Kyphosis (a thoracic hump), Tethered spinal cord syndrome, Occipitoatlantoaxial hypermobility,[8] Arnold-Chiari malformation (brain disorder)[9]
Functional bowel disorders (functional gastritis, irritable bowel syndrome)
Nerve compression disorders (carpal tunnel syndrome, acroparesthesia, neuropathy) [10]
Vascular skin conditions: Raynaud’s phenomenon, Livedo reticularis
Blue sclera
Otosclerosis (hearing loss)
Premature rupture of membranes during pregnancy
Platelet aggregation failure (platelets do not clump together properly)
Infants with hypermobile joints often appear to have weak muscle tone (hypotonia), which can delay the development of motor skills such as sitting, standing, and walking
Arterial/intestinal/uterine fragility or rupture
Swan neck deformity of the fingers
Because it is often undiagnosed or misdiagnosed in childhood, some instances of Ehlers–Danlos syndrome have been mischaracterized as child abuse. The pain associated with this condition is a serious complication.
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