Improved understanding of the infectious nature of dental diseases has dramatically increased interest in chemical methods of plaque control. The agent that has shown the most positive antibacterial results to date is chlorhexidine and diguanidohexane with pronounced antiseptic properties. Clinical studies have reported plaque reduction of 45% to 61% and gingivitis reduction of 27% to 67%.
Localized reversible side effects to chlorhexidine use may occur as brown staining of teeth and tongue and transient impairment of taste perception. It has got very low systemic toxic activity. The preparation contains 12% alcohol, which may be of concerns to alcohol increases risk of oropharyngeal cancer.
Essential oil mouth rinses contain thymol, eucalyptol, menthol and methyl salicylate. A preparation containing triclosan has shown some effectiveness in reducing plaque and gingivitis.