A Genetic Vulnerability with CNS involvement in TMDs

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    Anonymous
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    Most practicing dentists perceive the subject of temporomandibular
    joint (TMJ) diseases and disorders (TMJDs) as one of
    controversy, fueled by intense arguments about the relationship
    between the dental occlusion and the state of health of the
    masticatory system. Will dentistry ever again be able to think
    freely about this matter? How will we unravel the etiopathogenesis
    of the TMJDs when faced with strong convictions and
    consumed by an emotionally charged debate? When are
    negative results about the link between the occlusion and
    TMJDs sufficient to examine alternative lines of inquiry of the
    pathogenesis of TMJDs? How will we ever be in a position to
    isolate and reevaluate the uncomfortable factual irregularities
    that do not fit the prevailing explanatory models of TMJDs?
    How can one practice according to the evidence if the
    evidence is not predicted by the popular models of disease
    causation? It appears that we have reached a stage in
    understanding where the original literature needs to be reassessed
    based on BMethods and Materials[ and BResults[
    rather than the motivations and constructs expressed in the
    BIntroduction[ and BDiscussion[ sections. Influenced by
    powerful trends in science at-large, the field of TMJD is at a
    point where it is expected that traditional concepts will rapidly
    loose appeal and that the field of TMJD will gain significant
    new momentum.
    Seventy-five percent to 95% of primary care TMJD patients
    benefit from interventions administered by a range of health
    care professionals offering occlusal appliances, occlusal equilibration,
    thermal pads, a host of pharmacological interventions,
    orthodontics, crown and bridge treatment, surgery,
    physical therapy, relaxation training, acupuncture, biofeedback,
    and psychological and diet counseling. None of these
    remedies appears to promise a substantially better outcome
    over other types of therapy, although each treatment
    approach is believed to have its own underlying rationale
    and presumably unique mechanism of action.

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