Contraindications
Use of diazepam should be avoided, when possible, in individuals with the following conditions:[35]
Ataxia.
Severe hypoventilation.
Acute narrow-angle glaucoma.
Severe hepatic deficiencies (hepatitis and liver cirrhosis decrease elimination by a factor of 2).
Severe renal deficiencies (for example, patients on dialysis).
Liver disorders.
Severe respiratory disorders.
Severe sleep apnea.
Severe depression, particularly when accompanied by suicidal tendencies.
Psychosis.
Pregnancy or breast feeding.
Caution required in elderly or debilitated patients.
Coma or shock.
Abrupt discontinuation of therapy.
Acute intoxication with alcohol, narcotics, or other psychoactive substances (with the exception of some hallucinogens, where it is occasionally used as a treatment for overdose).
History of alcohol or drug dependence.
Myasthenia gravis, or MG, an autoimmune disorder causing marked fatiguability.
Hypersensitivity or allergy to any drug in the benzodiazepine class
