Important Interactions between Antibiotics and other drugs
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Interacting drug
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Effect
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Ciprofloxacin (and most other quinolones)
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Antacids, iron, sucralfate theophyline, cyclosporin, warfarin
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Decrease absoption of quinolones
Increase effect of theophyline, cyclosporine, warfarin
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NSAID
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Increase risk of CNS stimulation seizures
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Clindamycin
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Erythromycin
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Mutual antagonism
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Erythromycin
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Carbamazepine
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Inceases serum levels of carbamazepine causes nystagmus, ataxia, vomitting, (avoid this combination)
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Metronidazole
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Anticoagulants
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increases anticoagulant effect
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Phenobarbitones, hydantoins
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Decreases effect of metronidazole
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Tetracyclines
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antacids, iron, sucralfate,digoxin
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Decreases tetracycline effect Increases toxicity of digoxin (may persist for several months in 10% patients)
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