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When enamel, dentine and substances in caries lesions are exposed to (laser) light of a specific colour, fluorescence may be induced. This principle is at the basis of two caries diagnostic methods, DIAGNOdent and Quantitative Laser (Light-induced) Fluorescence (QLF). Only the DIAGNOdent is commercially available. Bacterial porphyrins evoke fluorescence when illuminated with red light and the intensity of the emitted light is related to the size of the caries lesion. Published research indicates that the DIAGNOdent is particularly suitable for detecting small bacteria containing caries lesions, and to monitor such lesions. QLF is based on the fluorescence decrease in demineralised enamel upon exposure to blue-violet (laser) light. The intensity of the emitted light is related to the amount of mineral loss in the caries lesion. Using QLF the mineral loss in caries lesions can be measured quantitatively. Like the DIAGNOdent, QLF is particularly suitable to monitor caries lesions.