Etiology
•Antimalarials,
•tranquilizers,
• minocycline,
• azidothymidine,
• ketoconazole,
•phenolphthalein, and
•others are the most common drugs that induce pigmentation.
Clinical features
The clinical picture varies, and the condition may appear as irregular brown or black macules or plaques, or diffuse melanosis (Fig. ).
The buccal mucosa, tongue, palate, and gingiva are the most commonly affected sites.
The diagnosis is made on the basis of the history and clinical criteria.
Differential diagnosis
•Normal pigmentation,
• Addison disease,
• Peutz–Jeghers syndrome.
Treatment
• No treatment is required.
