Erythema multiforme is a skin condition of unknown cause, possibly mediated by deposition of immune complex (mostly IgM) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. It is a common disorder, with peak incidence in the second and third decCauses
The most common predisposing infection is Herpes simplex, but bacterial infections (commonly Mycoplasma) and fungal diseases are also implicated. It has been shown that Herpes simplex virus suppression and even prophylaxis (with acyclovir) can prevent recurrent erythema multiforme eruption.
Other causes include drug reactions, most commonly to sulfa drugs, phenytoin, barbiturates, penicillin, and allopurinol, or a host of internal ailments.
The human form of orf can also cause erythema multiforme.
Persistent (chronic) erythema multiforme has been linked to ingestion of benzoates in both natural and artificial forms, including benzoic acid, which occurs naturally in some fruit, and sodium benzoate, a common food preservative.ades of life
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