Re: Mucoepidermoid carcinoma

[Anonymous]

DIFFERENTIAL DIAGNOSIS
MUCOEPIDERMOID CARCINOMA
Tumor composed of mucous, squamous and intermediate cells

Diagnostic Pearls

* Well circumscribed, cystic with mucin pools (low grade) or infiltrative, solid (high grade)
* Varying mixture of mucous, intermediate and epidermoid cells
* Uniform cells with intracytoplasmic mucin (low grade) or pleomorphic cells with little mucin (high grade)

ADENOID CYSTIC CARCINOMA
Cribriform pattern is common

Diagnostic Pearls

* Invasion of stroma and perineural invasion
* Basaloid cells forming cribriform structures, tubules or solid islands
* Chondromyxoid matrix is absent

WARTHIN S TUMOR
Cysts and glands with lymphoid stroma

Diagnostic Pearls

* Multiple large fluid filled cysts
* Double layered epithelial lining with columnar oncocytes and basal cells
* Heavy lymphoid stroma often with germinal centers