Re: Mucoepidermoid carcinoma

[Anonymous]

Special Stains and Immunohistochemistry

* Simple mucin-type carbohydrate antigens (T, Tn, and syalosyl-Tn) detected13
* Low-grade type:
o characteristic profile suggestive of striated duct differentiation:
+ CK7
+ CK14
+ mitochondrial antibodies

Staging/Grading

* Traditional two-tier system
* Three-grade scheme:
o proposed by AFIP authors17–19
o based on a points system:
+ intracystic component >20%, 2 points
+ neural invasion, 2 points
+ necrosis, 3 points
+ 4 or more mitoses per 10 HPF, 3 points
+ anaplasia, 4 points
o total score:
+ 0–4 low grade
+ 5–6 intermediate grade
+ ⩾ 7 high grade20