Cancrum oris

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  • #11952
    sushantpatel_docsushantpatel_doc
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    Registered On: 30/11/2009
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    Also called Noma or Gangrenous stomatitis.

    Noma is a type of gangrene that destroys mucous membranes of the mouth and other tissues. It occurs in malnourished children in areas of poor cleanliness.

    Causes, incidence, and risk factors

    The exact cause is unknown, but may be due to bacteria called fusospirochetal organisms.

    This disorder most often occurs in young, severely malnourished children between the ages of 2 and 5. Often they have had an illness such as measles, scarlet fever, tuberculosis, cancer, or immunodeficiency.

    Risk factors include Kwashiorkor and other forms of severe protein malnutrition, poor sanitation and poor cleanliness, disorders such as measles or leukemia, and living in an underdeveloped country.

    Symptoms

    Noma causes sudden, rapidly worsening tissue destruction. The gums and lining of the cheeks become inflamed and develop ulcers. The ulcers develop a foul-smelling drainage, causing breath odor and an odor to the skin.

    The infection spreads to the skin, and the tissues in the lips and cheeks die. The process can eventually destroy the soft tissue and bone. Eventual destruction of the bones around the mouth cause deformity and loss of teeth

    Noma can also affect the genitals, spreading to the genital skin (this is sometimes called noma pudendi).

    Signs and tests

    Physical examination shows inflamed areas of the mucous membranes, mouth ulcers, and skin ulcers. These ulcers have a foul-smelling drainage. There may be other signs of malnutrition.

    Treatment

    Antibiotics and proper nutrition helps stop the disease from getting worse. Plastic surgery may be necessary to remove destroyed tissues and reconstruct facial bones. This will improve facial appearance and the function of the mouth and jaw.

    Expectations (prognosis)

    In some cases, this condition can be deadly if left untreated. Other times, the condition may heal over time even without treatment. However, it can cause severe scarring and deformity.

    Complications

    Disfigurement

    Discomfort

    Calling your health care provider

    Medical care is needed if mouth sores and inflammation occur and persist or worsen.

    Prevention

    Measures to improve nutrition, cleanliness, and sanitation may be helpful.

    #17170
    Anonymous

    ANTIBIOTIC REGIME FOR TREATMENT

    most authors recommend penicillin + metronidazole. Agents used empirically to cover predominant organisms. Use tissue/blood cxs to tailor regimen. Rx for at least 14 days.
    * Preferred: penicillin G 2-4 million U IV q4h + metronidazole (Flagyl) 500mg IV q6-12h.
    * Alternative: ampicillin/sulbactam (Unasyn) 3.0g IV q6h.
    * PCN allergy: clindamycin (Cleocin) 600mg IV q8h.
    * Note: use of systemic abx in HIV pts may cause candidal overgrowth requiring additional antifungal coverage. Consider Nystatin rinses 5ml four times a day or fluconazole 200mg PO once daily.

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