Central giant cell granuloma

[tirath]

CGCG is a benign intraosseous lesion found in the anterior of the maxilla and the mandible in younger people (before age 20). It is characterized by large lesions that expand the cortical plate and can reabsorb roots and move teeth. It is composed of mulitnucleated giant cells. It has a slight predilection for females.
Radiographically it appears as multilocular radiolucencies of bone.
There are two types of CGCG’s, non-aggressive and aggressive. The former has a slow rate of growth and thus less likely to absorb roots and perforate the cortical plate. The aggressive form has rapid growth and thus is much more likely to absorb roots and perforate the cortical plate. It also has a high rate for recurrence and can be painful and cause paresthesia.

        

[Anonymous]

What is the differential diagnosis for this?
Can we give odontogenic keratocyst

        

[Anonymous]

DIFFERENTIAL DIAGNOSIS FOR CGCG:::

Ameloblastoma–uncommon in younger age as against CGCG
Anuerysmal bone cyst–doent occur in anterior portion of mandible like CGCG
Odontogenic myxoma–Shows multiloculated appearance and associated with missing or impacted teeth
Giant cell tumor–not preceeded by trauma
Traumatic bone cyst–No bodily movement of teeth and absence of thinning of cortex
Cherubism–Present bilaterally and posterior part of mandible,,history of familial involvement
Metastatic tumors, Surgical socket are few other DDs

        

[Anonymous]

Odontogenic keratocyst has a typical satellite appearance in which a large cyst in centre is surrounded by multiple small cysts all around…..radiographically
Associated commonly with GORLIN GOLTZ syndrome
MARFAN syndrome
EHLERS DANLOS syndrome
NOONAN s syndrome

        

[Anonymous]

how to differentiate Giant cell granuloma from Giant cell tumor

        

[Anonymous]

As mentioned in the post the tumor is not preceeded by trauma as in cgcg

        

[tirath]

p63 may be a useful biomarker to differentiate giant cell tumor of bone from central giant cell granuloma and other giant cell-rich tumors, such as giant cell tumor of tendon sheath and pigmented villonodular synovitis.

        

[Author]

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