Recent observations suggests that roxithromycin, a macrolide antibiotic, may have a therapeutic role in reducing cyclosporine-induced gingival overgrowth, owing to its inhibitory effect on transforming growth factor-beta production.15 Azithromycin has been used successfully.16,17,18
In addition, tacrolimus, a commonly used immunosuppressive agent, can become an alternative to cyclosporine-A use.19 However, tacrolimus can also induce gingival overgrowth, but this effect appears to be time related.20
Clinical studies comparing oral hygiene programs versus azithromycin indicate that azithromycin plus oral hygiene significantly reduces cyclosporine-induced gingival hyperplasia, while oral hygiene alone reduces oral symptoms but does not affect cyclosporine-induced gingival hyperplasia
Used to treat mild-to-moderate oral microbial infections. Clinical studies comparing oral hygiene programs vs azithromycin indicate that azithromycin plus oral hygiene significantly reduces cyclosporine-induced gingival hyperplasia, while oral hygiene alone reduces oral symptoms but does not affect cyclosporine- induced gingival hyperplasia.
Azithromycin is a macrolide antibiotic that acts by suppressing protein synthesis of gram-positive and gram-negative aerobes. Take 1-2 h pc.
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