Macroglossia is the medical term for unusual enlargement (hypertrophy) of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping. Amyloid Disorders
Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function.
* 1. Primary amyloidosis
* 2. Myeloma associated amyloidosis
* 3. Lubarsch Pick syndrome
* 4. Immunoglobulinemic amyloidosis
Hypothyroid Macroglossia
Macroglossia is also a clinical feature in Hypothyroid disorders which include
* 1. congenital hypothyroidism,.
* 2. Young Simpson syndrome,
* 3. Zadik Barak Levin syndrome,
* 4. Athyreotic cretinism
* 5. Kocher-Debre-Semelaigne syndrome
Overgrowth Disorders
* 1. Beckwith-Wiedemann syndrome
* 2. Simpson-Golabi-Behmel syndrome
* 3. Acromegaly
Chromosomal disorders
1. Triploid Syndrome
2. Chromosome 4,trisomy 4p
Other Miscellaneous
1. Mucopolysaccharidosis[10]
2. MANNOSIDOSIS, ALPHA B, LYSOSOMAL
3. Glycogen storage disease type 2, or Pompe’s disease.
4. Fucosidosis
Apparent macroglossia can also occur in Down syndrome
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