A research team at the University of Nebraska Medical Center has developed a new mouthwash formulation that may provide long-term protection against tooth decay.
The team, led by Dong Wang, Ph.D., associate professor of pharmaceutical science in the UNMC College of Pharmacy, has developed a novel drug delivery system to carry antimicrobial agents directly to teeth. Their study was published in the November issue of Antimicrobial Agents and Chemotherapy and was also reported in the Nov. 22 issue of Science Daily.
One of the main contributing factors to dental cavities is overpopulation of acid-producing bacteria in biofilm that is present on the tooth surface, eventually causing dental decay. Dr. Wang’s formulation would bind to the tooth surface and gradually release antimicrobials against cavity-forming bacteria such as Streptococcus mutans.
“The beauty of this design is the simplicity. All one may have to do is their routine oral hygiene procedure and then rinse with the formulation that we have developed. It could protect the teeth over a long period of time,†Dr. Wang said. “The key is to have the antimicrobials stay where they are most needed – the tooth surface.â€
In addition to its primary intent of cavity prevention for the general population, Dr. Wang’s formulation could have many far-reaching implications – for the elderly in nursing homes who may not have a lot of access to dental care and for protection against an increased risk of heart disease. A recent study found that poor dental hygiene leads to heart attack and stroke due to the bacteria having direct access to the bloodstream through bleeding gums.
“The general research theme here is to manipulate the drug concentration at its intended action sites,†he said.
Based upon the same principle, Dr. Wang’s research group also explores the potential of using the drug delivery systems that they have developed to improve the treatment of arthritis, cancer, and several other inflammatory diseases.
A PCT (Patent Cooperation Treaty) patent application has been filed on this technology through UNeMed, the technology transfer arm of UNMC. In addition to further development of this technology, Dr. Wang and his colleagues are looking for funds to support a clinical trial and for a cGMP (current Good Manufacturing Practice) facility to manufacture this formulation.
“This will be a great addition to the tools dentists have to fight tooth decay,” said Richard Reinhardt, Ph.D., D.D.S., co-director of undergraduate periodontics at the UNMC College of Dentistry and one of the research collaborators.
Lead author on the paper was graduate student Fu Chen, who conducted many of the experiments together with Xue Li, another coauthor of the paper. In addition to Dr. Reinhardt, other collaborators include Kenneth Bayles, Ph.D., professor of pathology and microbiology in the College of Medicine; Xin-Ming Liu, research assistant professor of pharmaceutical sciences in the College of Pharmacy, and Kelly Rice, Ph.D., from the University of Florida, Gainesville.
A bacteria-fighting formulation may not sound pleasing to the taste buds – but the group plans to work on that aspect to help ensure general use.
“We’ll sure look at different flavors. It must be something palatable,†Dr. Wang said.
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